- Title
- Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence
- Creator
- Golledge, Jonathan; Clancy, Paula; Yeap, Bu B.; Flicker, Leon; Norman, Paul E.; Hankey, Graeme J.; Maguire, Jane; Lincz, Lisa; Koblar, Simon; McEvoy, Mark; Attia, John; Levi, Chris; Sturm, Jonathan; Almeida, Osvaldo P.
- Relation
- Stroke Vol. 45, Issue 4, p. 1064-1068
- Publisher Link
- http://dx.doi.org/10.1161/STROKEAHA.113.004339
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2014
- Description
- Background and Purpose: Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. METHODS - : Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. Results: Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P<0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81-8.75 ng/mL for modified Rankin scale 3-6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75-9.92 ng/mL for modified Rankin scale 0-2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men. Conclusions: Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes.
- Subject
- angiopoietin-1; biological markers
- Identifier
- http://hdl.handle.net/1959.13/1305062
- Identifier
- uon:20967
- Identifier
- ISSN:0039-2499
- Language
- eng
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